Wagner P, Olsson H, Ranstam J, Robertsson O, Zheng MH, Lidgren L.

Metal-on-metal joint bearings and hematopoetic malignancy.

Acta Orthop. 2012 Dec;83(6):553-8.
Wagner P, Olsson H, Ranstam J, Robertsson O, Zheng MH, Lidgren L.This is a review of the hip arthroplasty era. We concentrate on new metal bearings, surface replacements, and the lessons not learned, and we highlight recent reports on malignancies and joint implants. A low incidence of blood malignancies has been found in bone marrow taken at prosthetic surgery. The incidence is increased after replacement with knee implants that release very low systemic levels of metal ions. A carcinogenic effect of the high levels of metal ions released by large metal-on-metal implants cannot be excluded. Ongoing Swedish implant registry studies going back to 1975 can serve as a basis for evaluation of this risk.
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